Papers in this monothematic issue are focused on area of study of development of human capital and management and in different type of organizations – mainly in educational organizations in different contexts of regional development and changes in society 4.0. The main aim of the issue is to describe different point of view in theory and practice of regional development in international context. Papers are based on the results of internal grant projects from The College of Regional Development and Banking Institute, AMBIS, a.s., Opinions on changes in working conditions in enterprises in the period 4.0 (IGA_01_2019) and the long term cooperation with universities in Russia - Moscow Polytechnic University and Technological University, Korolev, Moscow Region and with Mendel University in Brno, Faculty of Business and Economics, educational management Faculty of education, Charles University.